Methadone is a synthetic, long-acting opioid with pharmacologic actions qualitatively similar to morphine and is active by oral and parenteral routes of administration. It is primarily a μ-receptor agonist and may mimic endogenous opioids, enkephalins, and endorphins and affect the release of other neurotransmitters acetylcholine, norepinephrine, substance P, and dopamine.
This accounts for its analgesic and antitussive properties, respiratory depression, sedation, decrease in bowel motility, increase in biliary tone, hormone regulation and increase of prolactin and growth hormone release, miotic pupils, nausea, and hypotension. Patients develop tolerance and physical dependence following repeated use.
The tolerance may be only partial for most of the pharmacologic effects. An abstinence syndrome consisting of lacrimation, rhinorrhea, sneezing, gooseflesh, nausea, vomiting, fever, chills, tremor, and tachycardia occurs on abrupt discontinuation of the opiate or the administration of an antagonist such as naloxone hydrochloride. Buy methadone online
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Buy methadone online, There is cross-tolerance and cross-dependence among the various opiates. This is the premise for using methadone in the detoxification and maintenance of heroin people addicted to heroin. Due to the long half-life and duration of action of methadone, the abstinence syndrome is delayed and prolonged but less severe than that from a shorter-acting opiate such as heroin.
Methadone is a good therapeutic alternative to morphine sulfate and other opiate analgesics in the treatment of severe, chronic pain. It is well absorbed orally, has analgesic effects comparable to other μ-opiate receptor analgesics like morphine, has a long half-life, and is not metabolized to any active metabolites that may pose a risk to the patient.